Cisplatin-lnduced peripheral neurotoxicity is dependent on total-dose intensity and single-dose intensity
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چکیده
منابع مشابه
Dose intensity for breast cancer.
Despite nearly 20 years of study, the importance of chemotherapy dose intensity in breast cancer remains unclear. Substantial preclinical data suggest a dose-response relationship, and consistent data document that recipients of substandard dosing have inferior outcomes. The use of increased dose-intensive therapies is costly, may require the use of hematopoietic growth factor support, and can ...
متن کاملChemotherapy dose intensity and quality cancer care.
Myelosuppression continues to represent the major dose-limiting toxicity of cancer chemotherapy. Neutropenia and its complications, including febrile neutropenia, occur most often early in the course of treatment but are often underreported in clinical trials. In addition to associated morbidity, mortality, and cost, myelosuppression is often associated with reduced chemotherapy dose intensity....
متن کاملImpact of chemotherapy dose-density on radiotherapy dose-intensity after breast conserving surgery^ —j
r Purposes To evaluate if chemotherapy (CT) dose-intensification jeopardizes radiotherapy (RT) dose-intensity (DI). Patients and methods: From 1992 to 1997, 247 stage I—II breast cancer patients, treated with conserving surgery, were treated at the National Cancer Institute of Genoa in a randomized study comparing the same CEF regimen delivered every two weeks (CEF14) or three weeks (CEF21). RT...
متن کاملImpact of chemotherapy dose-density on radiotherapy dose-intensity after breast conserving surgery.
PURPOSE To evaluate if chemotherapy (CT) dose-intensification jeopardizes radiotherapy (RT) dose-intensity (DI). PATIENTS AND METHODS From 1992 to 1997, 247 stage I-II breast cancer patients, treated with conserving surgery, were treated at the National Cancer Institute of Genoa in a randomized study comparing the same CEF regimen delivered every two weeks (CEF14) or three weeks (CEF21). RT w...
متن کاملDose Distribution Analysis of Rapid Arc and Intensity Modulated Radiotherapy Plan in Head and Neck Cancer
Introduction: Globally, intensity-modulated radiation therapy (IMRT) is considered as highly precise and accurate method of radiotherapy planning. This technique amplifies spatial dose distribution conformity by modulating the intensity of radiation beams in each sub-volume. Additionally, it can reduces the dose to surrounding critical organs and deliver the planned dose to targets with the nom...
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ژورنال
عنوان ژورنال: Cancer
سال: 1992
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19920101)69:1<203::aid-cncr2820690133>3.0.co;2-1